GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs4493873 | 1 | rs4493873 | chr8:92075643 | LRRC69 | chr8:92114847-92231464:+ | -0.22 | -3.66 | 0.000278 | Migraine - clinic-based |
| THCA | cis | rs6499255 | 1 | rs4497676 | chr16:69814950 | COG4 | chr16:70514473-70557457:- | -0.2 | -4.01 | 7.08E-5 | IgE levels |
| THCA | cis | rs60843830 | 1 | rs4497901 | chr2:239969 | SH3YL1 | chr2:218138-264810:- | -0.93 | -25.53 | 2.54E-91 | Spherical equivalent (joint main effects and education interaction) |
| THCA | cis | rs10935120 | 1 | rs4498009 | chr3:134198008 | ANAPC13 | chr3:134196547-134204865:- | 0.39 | 12.44 | 5.93E-31 | Height |
| THCA | cis | rs10935120 | 1 | rs4498009 | chr3:134198008 | CEP63 | chr3:134204575-134293852:+ | 0.29 | 6.29 | 7.36E-10 | Height |
| THCA | cis | rs9929218 | 1 | rs4500718 | chr16:68754312 | NFATC3 | chr16:68118654-68260837:+ | -0.12 | -3.37 | 0.000821 | Colorectal cancer |
| THCA | cis | rs7200543 | 1 | rs4500751 | chr16:15140211 | NTAN1 | chr16:15131717-15149833:- | 0.14 | 4.07 | 5.48E-5 | Metabolic traits;Glycerophospholipid levels |
| THCA | cis | rs7200543 | 1 | rs4500751 | chr16:15140211 | PDXDC1 | chr16:15068599-15233195:+ | 0.31 | 7.32 | 1.04E-12 | Metabolic traits;Glycerophospholipid levels |
| THCA | cis | rs12216499 | 1 | rs4502963 | chr6:159369462 | RSPH3 | chr6:159398268-159421198:- | 0.28 | 6 | 3.97E-9 | Bladder cancer (smoking interaction) |
| THCA | cis | rs11014306 | 1 | rs4504964 | chr10:25208507 | PRTFDC1 | chr10:25137554-25241533:- | 0.25 | 3.43 | 0.000644 | Metabolite levels (Pyroglutamine) |
| THCA | cis | rs1926657 | 1 | rs4505186 | chr13:95878852 | ABCC4 | chr13:95672084-95953687:- | -0.18 | -3.41 | 0.000692 | Breast cancer |
| THCA | cis | rs3925075 | 1 | rs4506917 | chr16:31347350 | HSD3B7 | chr16:30996519-31000473:+ | -0.16 | -3.93 | 9.81E-5 | IgA nephropathy |
| THCA | cis | rs8042680 | 1 | rs4508401 | chr15:91514721 | HDDC3 | chr15:91474157-91475774:- | -0.15 | -4.27 | 2.39E-5 | Type 2 diabetes |
| THCA | cis | rs7762018 | 1 | rs4509126 | chr6:170068058 | C6orf70 | chr6:170151721-170181617:+ | 0.27 | 5.27 | 2.05E-7 | Thiazide-induced adverse metabolic effects in hypertensive patients |
| THCA | cis | rs7762018 | 1 | rs4509126 | chr6:170068058 | WDR27 | chr6:169857307-170102159:- | -0.2 | -6 | 3.97E-9 | Thiazide-induced adverse metabolic effects in hypertensive patients |